Melanotan I (afamelanotide) is a synthetic linear α-MSH analogue from the same 1990s research lineage as Melanotan II. Its profile is more selective for MC1R activation, producing pigmentation effects with less of the appetite and sexual-behavior modulation of MT-2.
Afamelanotide has been approved in research contexts for erythropoietic protoporphyria and is studied for vitiligo, polymorphic light eruption, and UV-induced skin damage.
- MC1R-selective pigmentation research
- Vitiligo and photoprotection studies
- UV-damage prevention models
- Libido and mood modulation investigation
- CAS
- 75921-69-6
- Formula
- C₇₈H₁₁₁N₂₁O₁₉
Lyophilized vial stable at 2–8 °C; -20 °C for long-term storage. Reconstitute with sterile bacteriostatic water; reconstituted solution stable for up to 30 days at 2–8 °C.
For research and laboratory use only. Not for human or veterinary consumption.
How to run this compound.
Add bacteriostatic water to the sealed vial. Swirl — do not shake. Refrigerate after reconstitution.
Reconstitute with bacteriostatic water. Subcutaneous administration on protocol cadence.
Run on the protocol schedule. The system rewards consistency over intensity.
Pair with complementary REFRAME lines. See suggestions below.